Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles
Vladislav V. Oreshko, Kseniya S. Kovaleva, Ekaterina D. Mordvinova, Оlga I. Yarovaya, Yu. V. Gatilov, Д. Н. Щербаков, Н. И. Бормотов, Olga А. Serova, Shishkina Ln, Нариман Ф. Салахутдинов
Abstract
A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (-)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.
Topics & Concepts
CamphorVacciniaMarburg virusChemistryVirusCombinatorial chemistryAnti virusVirologyBiologyOrganic chemistryBiochemistryEbola virusRecombinant DNAGeneSynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis of heterocyclic compounds