Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice
Érique Castro, Thayna S. Vieira, Tiago E. Oliveira, Milene Ortiz‐Silva, Maynara L. Andrade, Caroline A. Tomazelli, Álbert S. Peixoto, Cleyton R. Sobrinho, Mayara Franzoi Moreno, Gustavo R. Gilio, Rafael Junges Moreira, Raphael C. Guimarães, Luiz Augusto Perandini, Patrícia Chimin, Patrícia Reckziegel, Eduardo Hermógenes Moretti, Alexandre A. Steiner, Mathieu Laplante, William T. Festuccia
Abstract
BAT and iWAT mTORC2 is inhibited by cold acclimation, but its residual activity is required for cold-induced increases in total UCP-1 content and thermogenic capacity, but not glucose uptake and mTORC1 activity. The impaired BAT and iWAT total UCP-1 content and thermogenic capacity induced by adipocyte mTORC2 deficiency are compensated by activation of muscle shivering in cold-acclimated mice.