Interpenetrating network hydrogels for studying the role of matrix viscoelasticity in 3D osteocyte morphogenesis
Margherita Bernero, Doris Zauchner, Ralph Müller, Xiao‐Hua Qin
Abstract
3D osteocyte cultures reveal that fast stress-relaxing hydrogels enhance early osteocyte morphogenesis, while slow-relaxing hydrogels favor osteogenic differentiation after 14 days, highlighting their mechanosensitivity to matrix mechanics.
Topics & Concepts
Self-healing hydrogelsOsteocyteMorphogenesisMatrix (chemical analysis)ViscoelasticityChemistryExtracellular matrixBiophysicsMaterials scienceBiologyComposite materialBiochemistryPolymer chemistryIn vitroChromatographyOsteoblastGeneCellular Mechanics and Interactions3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications