Hydrosilane-Assisted Synthesis of Urea Derivatives from CO<sub>2</sub> and Amines
Yulei Zhao, Xuqiang Guo, Zhiyao Si, Yanan Hu, Ying Sun, Yun‐Lin Liu, Zhongyin Ji, Jinmao You
Abstract
A methodology employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives. This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate.
Topics & Concepts
PhenylsilaneChemistryUreaArylAlkylNucleophilic substitutionCombinatorial chemistryNucleophileOrganic chemistryCatalysisMedicinal chemistryCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCO2 Reduction Techniques and Catalysts