New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line
Youssef Draoui, Smaail Radi, Yousra Bahjou, Abderrazak Idir, Amal El Mahdaoui, Abdelmajid Zyad, Haralampos N. Miras, Marilena Ferbinţeanu, Aurelian Rotaru, Yann Garcia
Abstract
(4), for which the crystal structure was earlier determined. Notably, cadmium complexes 3 and 7 exhibit remarkable cytotoxicity and demonstrated a high selectivity index towards cancer cells when compared to peripheral blood mononuclear cells. Such activity highlights their potential function as anticancer agents.
Topics & Concepts
Triple-negative breast cancerChemistryCancer researchTriple negativeCancer cell linesCoordination complexTriazoleBreast cancerStereochemistryCombinatorial chemistryCancerBiologyMedicineInternal medicineCancer cellOrganic chemistryMetalClick Chemistry and ApplicationsSynthesis and biological activityAdvanced Breast Cancer Therapies