Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai
Topics & Concepts
NigericinInflammasomeAIM2Liver injuryNLRC4SecretionChemistryReactive oxygen speciesPharmacologyBiochemistryCaspase 1Cell biologyMedicineBiologyReceptorMembraneInflammasome and immune disordersDrug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and Treatment