Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (<i>Danio rerio</i>)
Meilan Feng, Juanjuan Luo, Yiping Wan, Jiannan Zhang, Chunjiao Lu, Maya Zhe Wang, Lu Dai, Xiaoqian Cao, Xiaojun Yang, Yajun Wang
Abstract
, were altered in zebrafish embryos for 24 h after nanoplastic exposure, indicating that the activation of the BER pathway would be stimulated after nanoplastic exposure in zebrafish embryos. Therefore, our findings illustrated that nanoplastics could induce developmental toxicity through activation of the oxidative stress response and BER pathways in zebrafish.
Topics & Concepts
ZebrafishOxidative stressDanioDevelopmental toxicitySuperoxide dismutaseXRCC1ToxicityBiologyCell biologyCatalaseAndrologyReactive oxygen speciesMolecular biologyChemistryBiochemistryGeneticsGeneMedicineGenotypeSingle-nucleotide polymorphismGestationOrganic chemistryPregnancyMicroplastics and Plastic Pollutionbiodegradable polymer synthesis and propertiesEffects and risks of endocrine disrupting chemicals