Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin
Xiufen Liu, Masanori Onda, Nathan Watson, Raffit Hassan, Mitchell Ho, Tapan K. Bera, Junxia Wei, Anirban Chakraborty, Richard Beers, Qi Zhou, Asif Shajahan, Parastoo Azadi, Jingyu Zhan, Di Xia, Ira Pastan
Abstract
SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.
Topics & Concepts
MesothelinMonoclonal antibodyCancer researchAntibodyBiologyImmunologyCAR-T cell therapy researchOccupational and environmental lung diseasesElectrostatic Discharge in Electronics