Protein-drug conjugate programmed by pH-reversible linker for tumor hypoxia relief and enhanced cancer combination therapy
Xican Zhang, Liangzhu Feng, Ziliang Dong, Xiaoqian Xin, Zhijuan Yang, Dashi Deng, Ernst Wagner, Zhuang Liu, Xiaowen Liu
Topics & Concepts
ConjugateLinkerChemistryClick chemistryIn vivoDrug deliveryCisplatinSystemic administrationTumor hypoxiaNitroimidazoleBiophysicsBiochemistryPharmacologyCombinatorial chemistryChemotherapyMedicineBiologyOrganic chemistryComputer scienceRadiation therapyOperating systemInternal medicineMathematicsBiotechnologySurgeryMathematical analysisCancer Research and TreatmentsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics