Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
Elisabeth Bou‐Petit, Stefan Hümmer, Helena Alarcon, Konstantin Slobodnyuk, Marta Cano-Galietero, Pedro Juan Barrios Fuentes, Pedro J. Guijarro, María José Muñoz, Leticia Suárez‐Cabrera, Anna Santamaría, Roger Estrada‐Tejedor, José I. Borrell, Santiago Ramón y Cajal
Abstract
represents therefore a promising starting point for the development of a novel generation of MNK inhibitors.
Topics & Concepts
ChemistryKinaseMode of actionCell biologySmall moleculeCancer researchRational designComputational biologyBiochemistryPharmacologyBiologyGeneticsMelanoma and MAPK PathwaysProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling