Isolation, identification and <i>in vivo</i> antihypertensive effect of novel angiotensin I-converting enzyme (ACE) inhibitory peptides from <i>Spirulina</i> protein hydrolysate
Qishan Suo, Yue Yang, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang
Abstract
By combining virtual screening and experimental assay, two angiotensin I-converting enzyme inhibitory peptides, TVLYEH and LQAGGLF, were identified from the protease K hydrolysate of Spirulina protein, and TVLYEH showed significantly antihypertensive effect in vivo .
Topics & Concepts
HydrolysateIn vivoSpirulina (dietary supplement)ChemistryEnzymeRenin–angiotensin systemProteaseBiochemistryPharmacologyBiologyEndocrinologyBiotechnologyHydrolysisBlood pressureRaw materialOrganic chemistryProtein Hydrolysis and Bioactive PeptidesRenin-Angiotensin System StudiesGDF15 and Related Biomarkers