Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis
Jiaxi Ren, Bin Ren, Tong Fu, Yanchun Ma, Ying Tan, Shuxiang Zhang, Yan Li, Qi Wang, Xing Chang, Ying Tong
Abstract
deletion. This discovery offers a novel insight into the molecular mechanisms underlying septic cardiomyopathy and suggests potential therapeutic targets for intervention.
Topics & Concepts
Mitochondrial biogenesisMitochondrial DNABiogenesisMitochondrionCardiomyopathyCell biologyMedicineChemistryCardiologyBiologyHeart failureBiochemistryGeneMitochondrial Function and PathologyATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism