Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
Zhiqian Zhang, Brandon Sie, Aiquan Chang, Yumei Leng, Christopher Nardone, Richard T. Timms, Stephen J. Elledge
Abstract
(Molecular Cell 83, 3377–3392.e1–e6; September 21, 2023) After publication, we noticed a minor error in Figure 2A. The rows of the heatmap were out of order and did not match the peptide name labels on the left side of the graphic. This was due to a mistake made during reformatting the figure to cluster the maps corresponding to the CRISPR data below it. The corrected version of the figure now appears with the paper online. Because the purpose of Figure 2A is to show examples of peptides with similar hydrophobic degron motifs, this error does not affect the interpretation of the paper. Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mappingZhang et al.Molecular CellSeptember 21, 2023In BriefZhang et al. combined a proteome-wide screen with machine learning to identify thousands of short linear motifs (degrons) in human proteins that are associated with sequence-dependent protein degradation. They went on to map critical residues, identify interacting ligases, and validate binding for a diverse collection of internal degrons. Full-Text PDF Open Access