Schiff Bases of Pioglitazone Provide Better Antidiabetic and Potent Antioxidant Effect in a Streptozotocin–Nicotinamide-Induced Diabetic Rodent Model
Hafiza Rabia Afzal, Najm ul Hassan Khan, Kishwar Sultana, Aisha Mobashar, Aqsa Lareb, Ayesha Khan, Abrashim Gull, Hasan Afzaal, Muhammad Tariq Khan, Muhammad Rizwan, Muhammad Imran
Abstract
< 0.001). Similarly, compound P3 produced significant and better results in comparison to pioglitazone in the rodent model. This study confirmed potent antidiabetic and superior antioxidant potential of the newly synthesized Schiff base (P3), which could ultimately account for insulin sensitization and for cellular protection and hence provide a potential clue for dual therapeutics.
Topics & Concepts
PioglitazonePharmacologyAntioxidantChemistryStreptozotocinIn vivoDiabetes mellitusThiazolidinedioneRosiglitazoneNicotinamideBiochemistryMedicineEndocrinologyType 2 diabetesReceptorEnzymeBiologyBiotechnologySynthesis and biological activityPeroxisome Proliferator-Activated ReceptorsAdenosine and Purinergic Signaling