Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation
Maria Dichiara, Antonia Artacho-Cordón, Rita Turnaturi, Miriam Santos-Caballero, Rafael González-Cano, Lorella Pasquinucci, Carla Barbaraci, Isabel Rodríguez-Gómez, Manuel Gómez-Guzmán, Agostino Marrazzo, Enrique J. Cobos, Emanuele Amata
Topics & Concepts
ChemistryThioamideAgonistPharmacologyReceptorIn vivoAmideAntagonistOpioid receptorStereochemistryCarboxamideAnalgesicChemical synthesisLigand (biochemistry)SelectivityReceptor antagonistLead compoundPharmacokineticsOpioidIn vitroδ-opioid receptorBenzazepineCombinatorial chemistryNK1 receptor antagonistStructure–activity relationshipFunctional selectivityBiological activityPharmacological Receptor Mechanisms and EffectsVagus Nerve Stimulation ResearchNicotinic Acetylcholine Receptors Study