Detection of Ofloxacin by Differential Pulse Voltammetry in Drugs Based on a Novel p-Aminobenzene Sulfonic Acid/Graphene Electrochemical Sensor
Xiaojing Si, Chen Bai, Xia Gong, Jingting Han, Zichao Chen, Yaping Ding
Abstract
This work demonstrates fabrication and performance (towards ofloxacin (OFL) detection) of a unique electrochemical sensor, composed of p-aminobenzene sulfonic acid (ASBA) and grapheme (GR). For this purpose, a glassy carbon electrode (GCE) was coated by GR using electrochemical deposition and then electro-polymerized by ABSA. The surface and morphology of the resulting composite pABSA/GR/GCE were analyzed using scanning electron microscopy. Oxidation peak currents obtained from the differential pulse voltammograms with the assistance of the composite pASBA/GR/GCE showed linear correlation to the OFL concentrations in the 0.1-40 μmol/L range with the detection limits of acetaminophen is 0.03 μmol/L (S/N = 3). We also demonstrated OFL detection using pASBA/GR/GCE in pharmaceutical formulations. These results indicate that pASBA/GR/GCE has very strong potential as an electro-analytical sensor for the detection of components in pharmaceutical formulations.