Synthesis of Diverse Aromatic Ketones through C−F Cleavage of Trifluoromethyl Group
Mai Ikeda, Tsubasa Matsuzawa, Takamoto Morita, Takamitsu Hosoya, Suguru Yoshida
Abstract
An efficient synthetic method of aromatic ketones through C-F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled multi-substituted aromatic ketone synthesis in an efficient route involving useful transformations such as ortho-lithiation, aryne chemistry, and cross-couplings.
Topics & Concepts
TrifluoromethylAryneKetoneChemistryCleavage (geology)Group (periodic table)Functional groupAromaticityStereochemistryOrganic chemistryMedicinal chemistryMoleculeMaterials scienceAlkylComposite materialFracture (geology)PolymerFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsCyclization and Aryne Chemistry