Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review
Shahram Torkamandi, Haleh Mikaeili, Amirhossein Sahebkar, Farhad Babaie, Melody Omraninava, Armita Mahdavi Gorabi, Arezou Khosrojerdi, Saeed Aslani, Arsalan Yazdchi, Thozhukat Sathyapalan
Abstract
Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options.