Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase
Bohang Zhou, Hui Li, Zhiming Cui, Ding Li, Huiling Geng, Jin‐Ming Gao, Le Zhou
Topics & Concepts
ChemistryAcetylcholinesteraseChelerythrineButyrylcholinesteraseCholinesteraseStereochemistryMoietyGalantaminePharmacologyEnzymeBiochemistryAchéDonepezilProtein kinase CMedicineDiseasePathologyDementiaCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsChemical synthesis and alkaloids