Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts
Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloé Guillas, Laetitia Pidial, Valérie Bellamy, Émilie Baron, Gwennhaël Autret, Keirththana Kamaleswaran, Chloé Pezzana, Marie‐Cécile Perier, José Vilar, A. Alberdi, Alain Brisson, Nisa Renault, Massimiliano Gnecchi, Jean‐Sébastien Silvestre, Philippe Menasché
Abstract
EV-CPC do not trigger cardiomyocyte proliferation but still improve cardiac function by other mechanisms which may include the regulation of fibrosis.
Topics & Concepts
Ejection fractionCardiac function curveEndogenyProgenitor cellMedicineGenetically modified mouseLigationRegeneration (biology)Myocardial infarctionTransgeneMyocyteStem cellCardiologyInternal medicineHeart failureAndrologyPathologyCell biologyChemistryBiologyGeneBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationTissue Engineering and Regenerative Medicine