Rapid changes in vascular compliance contribute to cerebrovascular adjustments during transient reductions in blood pressure in young, healthy adults
M. Erin Moir, Stephen A. Klassen, M. Zamir, J. Kevin Shoemaker
Abstract
Historically, dynamic cerebral autoregulation has been characterized by adjustments in cerebrovascular resistance following systematic changes in blood pressure. However, with the use of Windkessel modeling approaches, this study revealed rapid and large increases in cerebrovascular compliance that preceded reductions in cerebrovascular resistance following standing-induced blood pressure reductions. Importantly, the rapid cerebrovascular compliance response contributed to preservation of systolic blood velocity during the transient hypotensive phase. These results broaden our understanding of dynamic cerebral autoregulation.
Topics & Concepts
AutoregulationCerebral autoregulationBlood pressureCompliance (psychology)MedicineCardiologyVascular resistanceInternal medicineHemodynamicsAnesthesiaCerebral blood flowPsychologySocial psychologyTraumatic Brain Injury and Neurovascular DisturbancesOptical Imaging and Spectroscopy TechniquesRadiation Dose and Imaging