Thiophene-based organic dye with large Stokes shift and deep red emission for live cell NAD(P)H detection under varying chemical stimuli
Sushil K. Dwivedi, Dilka Liyana Arachchige, Adenike Mary Olowolagba, Mohamed E. Mahmoud, Jenna Cunnien, Daniel R. Tucker, Delaney Raine Fritz, Thomas Werner, Rudy L. Luck, Haiying Liu
Abstract
larvae. Notably, cisplatin treatment increased the NAD(P)H concentration in A459 cells over time. Overall, this work presents a significant advancement in the field of live cell imaging by providing a simple and cost-effective method for detecting changes in NAD(P)H concentration under varying chemical stimuli.
Topics & Concepts
CyanineNAD+ kinaseStokes shiftRed CellMaterials sciencePhotochemistryThiopheneChemistryOptoelectronicsFluorescenceBiochemistryOrganic chemistryPhysicsOpticsComputer scienceArtificial intelligenceEnzymeLuminescenceLuminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics