Combined photoredox/engineered P450 enzymatic direct dioxygen-functionalization of arylalkanes to chiral acyloins
Jing Wang, Hezhen Wang, Chunyong Wei, Lei Zhang, Bao‐Dong Cui, Zhongqiang Wang, Yun Zhang, Nan‐Wei Wan, Haji Akber Aisa, Yong‐Zheng Chen
Abstract
was developed by the direct carbonylation of aromatic methyl C-H bonds and subsequently combined with the aerobic P450-biocatalytic enantioselective hydroxylation of intermediate ketones, thus providing a green and sustainable approach towards optically pure acyloins.
Topics & Concepts
ChemistryHydroxylationPhotoredox catalysisCombinatorial chemistrySurface modificationEnantioselective synthesisCatalysisBiocatalysisOrganocatalysisRedoxCarbonylationOrganic chemistryEnzymePhotocatalysisReaction mechanismPhysical chemistryCarbon monoxideCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques