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Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses neutrophil extracellular trap formation and promotes diabetic wound healing via PGE2/BMAL1 pathway

Lulu Lin, Liang Xiao, Zhihong Xu, Yueying Li, Yueying Li, Zihan Guo, Liu Liu, Hanhui Liu, Qing Cai, Yun Chen, Zhui Yu, Yinping Li, Yinping Li

2025Biomaterials9 citationsDOI

Topics & Concepts

Mesenchymal stem cellNeutrophil extracellular trapsCell biologyWound healingDownregulation and upregulationChemistryExtracellularIn vivoProstaglandin E2PharmacologyCell therapyMyofibroblastCellCancer researchIntracellularTransfectionProstaglandinIn vitroHyaluronic acidReactive oxygen speciesSelf-healing hydrogelsTissue engineeringNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerNanoplatforms for cancer theranostics
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses neutrophil extracellular trap formation and promotes diabetic wound healing via PGE2/BMAL1 pathway | Litcius