γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy
Fangyuan Zhou, Shikui Yang, Chao Zhao, Wangwang Liu, Xufeng Yao, Hui Yu, Xiaolian Sun, Yi Liu
Abstract
NRh-G-NPs were specifically responsive to GGT overexpressed in U87MG tumor cells and selectively lit up the tumor for imaging-guided therapy. Besides, the recovery of photothermal property in the tumor area could improve cancer therapy precision and decreased side effects in normal tissues.
Topics & Concepts
Photothermal therapyTumor microenvironmentFluorescenceMolecular imagingBiomarkerCancer researchFluorescence-lifetime imaging microscopyChemistryBiophysicsNanotechnologyMaterials scienceTumor cellsMedicineBiologyIn vivoBiochemistryBiotechnologyPhysicsQuantum mechanicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer Research and Treatments