Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of <i>N</i>-(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer
Bharvi Sharma, Sourav Saha, Shanen Perumal, Liang Gu, Oluwakemi Ebenezer, Parvesh Singh, Mandeep Kaur, Vipan Kumar
Abstract
values of 13.61 and 22.76 μM against MCF-7 (ER+) and MDA-MB-231 (ER-) cells, respectively. The docking studies were found to be consistent with experimental results owing to the stronger binding affinity of the synthesized conjugates via hydrophobic and H-bonding interactions.
Topics & Concepts
Triple-negative breast cancerTriple bondBreast cancerCancer researchChemistryCancerComputational biologyCombinatorial chemistryBiologyGeneticsOrganic chemistryDouble bondSynthesis and bioactivity of alkaloidsMulticomponent Synthesis of HeterocyclesSynthesis and Biological Evaluation