AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides
Amanda M. Acevedo‐Jake, Andrew T. Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel Singleton, Ali Tavassoli, Stephen M. Goldup
Abstract
We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
Topics & Concepts
ChemistryOligonucleotideCombinatorial chemistryDNAStereochemistryBiochemistryDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery