Catalytic Olefin–Imine Metathesis: Cobalt-Enabled Amidine Olefination with Enaminones
Shuaixin Fan, Wei-Ping Wu, Lili Fang, Jin Zhu
Abstract
Organic metathesis reactions allow for expedient assembly of diverse molecular skeletons and appendages through the exchange of molecular fragments. The olefin-imine variant of this process, in particular, can expand the synthetic toolbox for manipulating carbon-carbon and carbon-nitrogen bonds but has thus far been achieved only on a stoichiometric metal-mediated basis. Herein, we report the development of a catalytic olefin-imine metathesis reaction, featuring cobalt-catalyzed amidine olefination with enaminones and a versatile product synthon enabling further structural diversification.
Topics & Concepts
ChemistryImineAmidineCatalysisOlefin metathesisSynthonMetathesisCombinatorial chemistryOlefin fiberSalt metathesis reactionOrganic chemistryCobaltAlkenePolymerizationPolymerSynthetic Organic Chemistry MethodsChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis