Harnessing α-<scp>l</scp>-fucosidase for <i>in vivo</i> cellular senescence imaging
Seyoung Koo, Miae Won, Hao Li, Won Young Kim, Mingle Li, Chenxu Yan, Amit Sharma, Zhiqian Guo, Weihong Zhu, Jonathan L. Sessler, Jin Yong Lee, Jong Seung Kim
Abstract
Evidence of close association of α-fuc with senescence induction highlights the potential of α-fuc as a novel biomarker for cellular senescence. Here, an α-fuc-responsive AIE probe (<bold>QM-NHαfuc</bold>) allows for the identification of senescent cell <italic>in vivo</italic>.
Topics & Concepts
SenescenceIn vivoCellular senescenceBiomarkerCell biologyIdentification (biology)BiologyEx vivoCellComputational biologyChemistryBiochemistryPhenotypeGeneticsGeneBotanyAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials