Pocahemiketone A, a Sesquiterpenoid Possessing a Spirocyclic Skeleton with a Hemiketal Endoperoxide Unit, Alleviates Aβ<sub>25–35</sub>-Induced Pyroptosis and Oxidative Stress in SH-SY5Y Cells
Qin‐Mei Zhou, Haoyu Zhao, Chuan Ma, Lu Huang, Jie Liu, Li Guo, Cheng Peng, Liang Xiong
Abstract
Pocahemiketone A, a novel sesquiterpenoid possessing a unique spirocyclic skeleton with a hemiketal endoperoxide unit, was isolated from the essential oil of Pogostemon cablin. Its structure was determined by spectroscopic methods and single-crystal X-ray diffraction analyses. Pocahemiketone A exhibits a significant neuroprotective effect against Aβ25–35-induced damage in SH-SY5Y cells by inhibiting NLRP3 inflammasome-mediated pyroptosis and oxidative stress. These results indicate that pocahemiketone A has great potential for use in the treatment of Alzheimer′s disease.
Topics & Concepts
ChemistryPyroptosisNeuroprotectionStereochemistryOxidative stressSH-SY5YInflammasomeBiochemistryPharmacologyNeuroblastomaBiologyMedicineCell cultureReceptorGeneticsPhytochemistry and Biological ActivitiesPlant-derived Lignans Synthesis and BioactivityInflammasome and immune disorders