Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint
Ravindra Thakkar, Deepa Upreti, Susumu Ishiguro, Masaaki Tamura, Jeffrey Comer
Abstract
) using bio-layer interferometry. Treatment with this peptide inhibited tumor growth in a co-culture of Lewis lung carcinoma (LLC) cells and antigen primed T cells, as well as in mice with an orthotropic Lewis lung carcinoma allograft model.
Topics & Concepts
PeptideCyclic peptideDocking (animal)ChemistryCancer researchBiophysicsMaterials scienceBiologyBiochemistryMedicineNursingCancer Immunotherapy and BiomarkersPeptidase Inhibition and AnalysisMonoclonal and Polyclonal Antibodies Research