Copper-Catalyzed Three-Component Synthesis of β-Hydroxysulfides from Styrene Oxide, Aryl Iodide, and Carbon Disulfide
Enbo Yu, Jun Li, Yue Wang, Ya Chen, Fuhong Xiao, Guo‐Jun Deng
Abstract
A copper-catalyzed three-component coupling reaction of styrene oxide, aryl iodide, and carbon disulfide for the construction of β-hydroxysulfides has been developed. In this process, readily available CS 2 was used as the sulfur source to construct C–S bonds for the synthesis of phenyl-β-hydroxysulfides and (benzo[ d ]thiazol)-β-hydroxysulfides. This process features mild reaction conditions, simple operation, and wide substrate scope (>50 examples).
Topics & Concepts
ChemistryStyrene oxideArylCarbon disulfideCatalysisStyreneIodideOxideCoupling reactionSulfurCopperSubstrate (aquarium)Polymer chemistryOrganic chemistryCopolymerAlkylOceanographyGeologyPolymerSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions