Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
John P. Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins, David M. Stresser
Topics & Concepts
ChemistryCytochrome P450CYP3A4PharmacologyCYP1A2Enzyme inducerBiologyBiochemistryEnzymePharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects and Toxicity Studies