Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento‐Tormo, Tzachi Hagai, Xi Chen, Muzlifah Haniffa, Jacqueline D. Shields, Sarah A. Teichmann
Abstract
macrophages, and perturbation of C3a and C3aR disrupts immune infiltration, slowing tumor growth. Our results highlight the power of scRNA-seq to identify complex interplays and increase stromal diversity as a tumor develops, revealing that stromal cells acquire the capacity to modulate immune landscapes from early disease.
Topics & Concepts
NicheStromal cellRNABiologyComputational biologyCell biologyCellCell growthGeneticsGeneCancer researchBiochemistrySingle-cell and spatial transcriptomicsCancer Genomics and DiagnosticsCancer Cells and Metastasis