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Sulforaphene, a CDK5 Inhibitor, attenuates cognitive deficits in a transgenic mouse model of Alzheimer’s disease via reducing Aβ Deposition, tau hyperphosphorylation and synaptic dysfunction

Wen Yang, Qingqing Xu, Qiuju Yuan, Yan‐Fang Xian, Zhi‐Xiu Lin

2022International Immunopharmacology30 citationsDOI

Topics & Concepts

Cyclin-dependent kinase 5Synaptic plasticityHyperphosphorylationNeuroscienceMorris water navigation taskNeurotoxicityGenetically modified mouseAlzheimer's diseasePharmacologyKinaseChemistryPsychologyTransgeneProtein kinase ABiologyMedicineInternal medicineBiochemistryHippocampusDiseaseToxicityReceptorCyclin-dependent kinase 2GeneGenomics, phytochemicals, and oxidative stressAlzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms
Sulforaphene, a CDK5 Inhibitor, attenuates cognitive deficits in a transgenic mouse model of Alzheimer’s disease via reducing Aβ Deposition, tau hyperphosphorylation and synaptic dysfunction | Litcius