The Transcriptional Aftermath in Two Independently Formed Hybrids of the Opportunistic Pathogen Candida orthopsilosis
Hrant Hovhannisyan, Ester Saus, Ewa Księżopolska, Toni Gabaldón
Abstract
How new pathogens emerge is an important question that remains largely unanswered. Some emerging yeast pathogens are hybrids originated through the crossing of two different species, but how hybridization contributes to higher virulence is unclear. Here, we show that hybrids selectively retain gene regulation plasticity inherited from the two parents and that this plasticity affects genes involved in virulence.
Topics & Concepts
BiologyVirulenceHybridOpportunistic pathogenGenePathogenGeneticsFungal pathogenYeastMicrobiologyBotanyAntifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research