Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis
Li Sun, Chao‐Yuan Huang, Miaolin Zhu, Shuwei Guo, Qiuzhi Gao, Qianqian Wang, Bin Chen, Rong Li, Yuanyuan Zhao, Mei Wang, Zhihong Chen, Bo Shen, Wei Zhu
Abstract
Overall, our data indicated that GCMSCs enriched CSC-like cells in GC cells, which gives a new insight into the mechanism of GCMSCs prompting GC progression and provides a potential combined therapeutic target.
Topics & Concepts
Mesenchymal stem cellCancer stem cellCarcinogenesisCancer researchStem cellCancerCTCFCancer cellCell biologyChemistryBiologyMedicineInternal medicineTranscription factorGeneBiochemistryEnhancerCancer Cells and MetastasisCancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers