Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria
Helal Abujubara, Jordi C. J. Hintzen, Shadi Rahimi, Ivan Mijakovic̀, Daniel Tietze, Alesia A. Tietze
Abstract
, manifesting it as a potential future drug lead. This could lead to treatments for MRSA infections in clinics and diseases such as septic arthritis, which has been directly linked with SrtA.
Topics & Concepts
VirulenceVirulence factorSortase AMicrobiologyBacteriaSortaseGramPathogenic bacteriaBiologyChemistryBacterial proteinBiochemistryGeneticsGeneBiochemical and Structural CharacterizationGlycosylation and Glycoproteins ResearchTransgenic Plants and Applications