Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells
Norihito Shibata, Nobumichi Ohoka, Genichiro Tsuji, Yosuke Demizu, Keiji Miyawaza, Kumiko Ui‐Tei, Tetsu Akiyama, Mikihiko Naito
Topics & Concepts
BiologyABLChronic myelogenous leukemiaCancer researchFusion proteinPhiladelphia chromosomeLeukemiaFusion geneProtein degradationbreakpoint cluster regionUbiquitinTyrosine kinaseMolecular biologyCell biologySignal transductionGeneChromosomal translocationImmunologyBiochemistryRecombinant DNAProtein Degradation and InhibitorsChronic Myeloid Leukemia TreatmentsPeptidase Inhibition and Analysis