Dynamic PET/CT imaging of <sup>18</sup>F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.
Xiaoxia Xu, Hua Zhu, Fei Liu, Yan Zhang, Jianhua Yang, Lifang Zhang, Qing Xie, Lin Zhu, Nan Li, Hank F. Kung, Zhi Yang
Abstract
PURPOSE: F-FGln PET/CT images of healthy subjects and cancer patients and explore the best imaging phase for different cancers. METHODS: F-FGln/PET at different scan phases were compared. RESULTS: F-FGln PET/CT imaging phases. The peak of SUVmax in breast and thyroid cancers was within 10 min, while in lung cancers, the plateau of SUVmax was within 30 min to 60 min. The SURs of lung cancer (p = 0.046) and thyroid cancer (p = 0.794) increased from the early-phase to the late-phase acquisition; however, a significant decrease was observed in the breast lesions (p = 0.022). CONCLUSIONS: F-FGln PET/CT needs to be optimized for different cancer types to improve the contrast resolution of tumors.