Multicomponent Click Reaction: An Indispensable Tool for Easy Access of Functionalized 1,2,3‐Triazoles
Mangal S. Yadav, Sanchayita Rajkhowa, Sumit K. Singh, Manoj K. Jaiswal, Vinod K. Tiwari
Abstract
Abstract Multicomponent reactions are operationally simple and display a significant role in diverse chemical modification by reducing reaction times as well as additional steps involved. In this review, we highlighted the impact of multi‐component reactions in assistance with modular Click chemistry to develop a library of triazole‐appended scaffolds including 1,2,3‐triazole‐fused heterocycles, glycoconjugates, macrocycles as well as in the combinatorial synthesis of differently functionalized triazoles along with mechanistic insights with a diverse range of applications in the field of medicinal chemistry.
Topics & Concepts
Click chemistryModular designCombinatorial chemistryTriazoleComputer scienceChemistryNanotechnologyOrganic chemistryMaterials scienceProgramming languageClick Chemistry and ApplicationsChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research