Effect of Modification Strategies on the Biological Activity of Peptides/Proteins
Jian Ma, Yan Liang, Jingkui Yang, Yujian He, Li Wu
Abstract
Covalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.
Topics & Concepts
BiodistributionChemistryBiological activityPeptideBiochemistryPosttranslational modificationCovalent bondEnzymeCombinatorial chemistryComputational biologyBiologyIn vitroOrganic chemistryProtein Hydrolysis and Bioactive PeptidesChemical Synthesis and AnalysisPeptidase Inhibition and Analysis