Copper-catalyzed asymmetric 1,6-conjugate addition of <i>in situ</i> generated <i>para</i>-quinone methides with β-ketoesters
Yi-Feng Wang, Chaojie Wang, Qing-Zhou Feng, Jing-Jing Zhai, Suo‐Suo Qi, Aiguo Zhong, Mingming Chu, Dan‐Qian Xu
Abstract
The first example of transition metal catalyzed asymmetric transformations of the in situ generated p -QMs has been developed, avoiding using pre-synthesized p -QMs requiring bulky 2,6-substitutions.
Topics & Concepts
StereocenterOxazolineChemistryConjugateIn situCatalysisQuinoneCopperMetalLewis acids and basesBrønsted–Lowry acid–base theoryCombinatorial chemistryEnantioselective synthesisStereochemistryOrganic chemistryMathematicsMathematical analysisSynthesis of Indole DerivativesChemical Synthesis and ReactionsAxial and Atropisomeric Chirality Synthesis