Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy
Songtao Du, Furong Zeng, Guangtong Deng
Abstract
In a recent study published in Nature, Kim et al. demonstrated that ferroptosis of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) causes immune suppression in cancer, 1 highlighting ferroptosis inhibition as a targetable therapeutic strategy for cancer immunotherapy.
Topics & Concepts
ImmunotherapyCancerMechanism (biology)Cancer immunotherapyImmunologyTumor immunologyMedicineCancer researchImmune systemInternal medicinePhilosophyEpistemologyFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersImmune cells in cancer