Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst
Viktoriia Zubar, Abhishek Dewanji, Magnus Rueping
Abstract
The reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperative catalysis.
Topics & Concepts
ChemistryAnilineCatalysisBifunctionalManganeseBase (topology)Combinatorial chemistryMetalLigand (biochemistry)Base metalReaction conditionsOrganic chemistryWeldingMaterials scienceMetallurgyBiochemistryMathematicsReceptorMathematical analysisNanomaterials for catalytic reactionsAsymmetric Hydrogenation and CatalysisAmmonia Synthesis and Nitrogen Reduction