Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of <i>K. pneumoniae</i>: An epidemiological, genomic and functional study
Ping Li, Qiqiang Liang, Wugao Liu, Beiwen Zheng, Lizhang Liu, Wei Wang, Zhijiang Xu, Man Huang, Youjun Feng
Abstract
-harboring resistance plasmids. In addition to the prevalent pLVKP-like virulence plasmid variants (~178kb), we found an unexpected diversity among KPC-2-producing plasmids whose dominant form is IncFII-IncR type (~120kb), rather than the previously anticipated version of ~170kb. These findings provide an updated snapshot of convergence of hypervirulence and carbapenem resistance in ST11
Topics & Concepts
VirulencePlasmidBiologyMicrobiologyKlebsiella pneumoniaeCarbapenemMultilocus sequence typingAntibiotic resistanceGeneGenotypeGeneticsAntibioticsEscherichia coliAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingAntimicrobial Resistance in Staphylococcus