Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria
Jim E. Horne, David J. Brockwell, Sheena E. Radford
Abstract
Current models of OMP biogenesis in the cellular environment are still in flux, but the stakes for improving the accuracy of these models are high. OMP folding is an essential process in all Gram-negative bacteria, and considering the looming crisis of widespread microbial drug resistance it is an attractive target. To bring down this vital OMP-supported barrier to antibiotics, we must first understand how bacterial cells build it.
Topics & Concepts
Bacterial outer membraneGram-negative bacteriaBacteriaProtein foldingBiologyBiogenesisLipid bilayerLipid AFolding (DSP implementation)Cell biologyBiophysicsMicrobiologyMembraneBiochemistryEscherichia coliGeneticsElectrical engineeringEngineeringGeneLipid Membrane Structure and BehaviorBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria