Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine
Max Van Hoof, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
Topics & Concepts
CXC chemokine receptorsChemistryAntagonismPyrimidineStereochemistryAngiogenesisScaffoldChemokine receptorCombinatorial chemistryCancer researchChemokineBiochemistryReceptorBiologyBiomedical engineeringMedicineChemokine receptors and signalingMulticomponent Synthesis of HeterocyclesSynthesis and biological activity