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Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury

Guoqiang Zhang, Lin Chen, Yuanjie Wen, Zhi Rao, Yuhui Wei, Xinan Wu

2020Toxicology and Applied Pharmacology18 citationsDOI

Topics & Concepts

Farnesoid X receptorObeticholic acidCholesterol 7 alpha-hydroxylaseChemistryBile acidAgonistInternal medicinePharmacologyLiver injuryEndocrinologyG protein-coupled bile acid receptorSmall heterodimer partnerNuclear receptorReceptorBiochemistryMedicineTranscription factorGeneDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects and Toxicity Studies
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury | Litcius