Synergistic FRET assays for drug discovery targeting RyR2 channels
RobynT. Rebbeck, Kenneth S. Ginsburg, Christopher Y. Ko, Anna Fasoli, Katherine Rusch, George F. Cai, Xiaoqiong Dong, David D. Thomas, Donald M. Bers, Rǎzvan L. Cornea
Topics & Concepts
Ryanodine receptor 2Drug discoveryRyanodine receptorCalmodulinChemistryHigh-throughput screeningEndoplasmic reticulumSmall moleculeBiophysicsCell biologyPharmacologyBiologyBiochemistryEnzymeCardiac electrophysiology and arrhythmiasIon channel regulation and functionReceptor Mechanisms and Signaling